Details

Autor(en) / Beteiligte

• Chang, Mengyu
• Hou, Zhiyao
• Wang, Man
• Wen, Ding
• Li, Chunxia
• Liu, Yuhui
• Zhao, Yanli
• Lin, Jun

Titel

Cu Single Atom Nanozyme Based High‐Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation

Ist Teil von

• Angewandte Chemie International Edition, 2022-12, Vol.61 (50), p.e202209245-n/a

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP‐silencing induced mild PTT. On one hand, LIK066 inhibits glucose uptake by shutting sodium‐dependent glucose transporter (SGLT) “valve”, effectively blocking the energy source for adenosine triphosphate (ATP) generation. Without sufficient energy, cancer cells cannot synthesize HSPs. On the other hand, Cu SAzyme presents extraordinary multienzyme activities to induce reactive oxygen species (ROS) storm formation, which can damage the existing HSPs in cancer cells. Through a two‐pronged strategy of SGLT inhibitor and ROS storm, LIK066‐loaded Cu SAzyme shows high efficiency for comprehensive removal of HSPs to realize mild PTT. A Cu single atom nanozyme achieves mild photothermal cancer therapy by a two‐pronged strategy, where the delivered clinical medicine licogliflozin closes a sodium‐dependent glucose transporter valve for blocking the energy required for the synthesis of heat shock proteins (HSPs). Meanwhile, the nanozyme forms a reactive oxygen species storm to damage existing HSPs.