Details

Autor(en) / Beteiligte

• Sacher, Sara E.
• Neri, John P.
• Gao, Madeleine A.
• Argentieri, Erin C.
• Potter, Hollis G.
• Koch, Kevin M.
• Koff, Matthew F.

Titel

MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty

Ist Teil von

• Journal of orthopaedic research, 2023-06, Vol.41 (6), p.1299-1309

Ort / Verlag

United States

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The infrapatellar fat pad (IPFP) has been implicated as a source of postoperative knee pain. Imaging the IPFP is challenging in patients with total knee arthroplasty (TKA) due to metallic susceptibility artifact. Multi‐Acquisition Variable‐Resonance Image Combination (MAVRIC)‐based T2 Mapping has been developed to mitigate this artifact and can generate quantitative T2 data. Objectives of this study were to (1) measure T2 values of the IPFP in patients with TKAs using a MAVRIC based T2 mapping technique and (2) determine if IPFP T2 values are related to the degree of fat pad scarring or clinical magnetic resonance imaging (MRI) findings. Twenty‐eight subjects (10 males, 18 females, Age: 66 + 7.2 years [Mean ± standard deviations]) undergoing clinical MRIs were sequentially recruited. Morphological imaging and quantitative T2 mapping sequences were performed on a clinical 1.5 T scanner. The morphologic images were graded for the presence and severity of fat pad scarring and clinical outcomes. T2 values were calculated in the total fat pad volume, a normal regions of interest (ROI), and an abnormal ROI. T2 values were shortened in the total IPFP volume (p = 0.001) and within abnormal regions (p = 0.003) in subjects with more severe IPFP scarring. The difference between T2 values in normal−abnormal regions was greater in subjects with severe versus no scarring (+1426.1%, p = 0.008). T2 values were elevated in patients with MRI findings of osteolysis (+32.3%, p = 0.02). These findings indicate that MAVRIC‐based T2 Mapping may be used as a quantitative biomarker of postoperative IPFP scarring in individuals following TKA. Multi‐Acquisition Variable‐Resonance Image Combination (MAVRIC)‐based T2 mapping was used to mitigate artifact and generate quantitative T2 values of the infrapatellar fat pad (IPFP) in individuals with total knee arthroplasty (TKA). T2 values were shortened in individuals with more severe IPFP scarring and elevated in individuals with magnetic resonance imaging findings of osteolysis. These findings indicate that MAVRIC‐based T2 Mapping may be used as a quantitative biomarker of postoperative IPFP scarring in individuals following TKA.