Details

Autor(en) / Beteiligte

• Liu, Min
• Zhang, Jian Feng
• Zhu, Wen Long
• Liu, Huan
• Jia, Xiong

Titel

Loureirin B protects against obesity via activation of adipose tissue ω3 PUFA-GPR120-UCP1 axis in mice

Ist Teil von

• Biochemical and biophysical research communications, 2022-12, Vol.632, p.139-149

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Obesity and related metabolic disorders are worldwide epidemics. Current lifestyle interventions and drug treatment for obesity seem insufficient. Here, we show that Loureirin B (LB), a major flavonoid molecule extracted from Sanguis Draxonis, prevents diet-induced obesity and ameliorates concomitant metabolic abnormalities including fatty liver, insulin resistance and systemic inflammation in mice. Mechanistically, LB treatment increases the proportion of ω3 polyunsaturated fatty acids (PUFAs) in brown adipose tissue (BAT) and white adipose tissue (WAT), which subsequently activates the key lipid sensor GPR120. In line with this, LB treatment promotes browning of WAT and activates BAT thermogenesis through upregulation of UCP1, a downstream effector of GPR120. Conversely, inhibition of GPR120 abolishes the thermogenic effect of LB in primary cultured brown adipocytes. Together, these results suggest that LB possesses anti-obesity property by enhancing adipose tissue thermogenesis via activation of ω3 PUFA-GPR120-UCP1 axis and holds promises for combating obesity and its related metabolic syndrome. •Loureirin B treatment prevents high-fat diet induced obesity in mice.•Loureirin B reduces adipose tissue mass and increases ω3 polyunsaturated fatty acids (PUFAs).•Loureirin B-mediated ω3 PUFAs elevation activates G-protein coupled receptor 120 (GPR120) resulting in increased thermogenesis in both BAT and WAT.•Loureirin B exerts anti-obesity effects through activation of adipose tissue thermogenesis via ω3 PUFAs-GPR120-UCP1 axis.