Details

Autor(en) / Beteiligte

• Shapira, Suzanne N.
• Naji, Ali
• Atkinson, Mark A.
• Powers, Alvin C.
• Kaestner, Klaus H.

Titel

Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program

Ist Teil von

• Cell metabolism, 2022-12, Vol.34 (12), p.1906-1913

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community. Using a collaborative, multi-institutional approach, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D) studies the molecular pathogenesis of islet dysfunction in type 2 diabetes. All data generated by the program are made immediately and freely accessible, thus providing a valuable resource for the diabetes research community.