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Intravenous Immune Globulin Therapy in Dermatomyositis
Ist Teil von
The New England journal of medicine, 2022-10, Vol.387 (14), p.1320-1321
Ort / Verlag
Boston: Massachusetts Medical Society
Erscheinungsjahr
2022
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Dermatomyositis is a heterogeneous syndrome with several associated antibodies, such as those against transcription intermediary factor 1-γ (anti–TIF-1γ), melanoma differentiation-associated gene 5 (anti–MDA-5), nuclear matrix protein 2 (anti–NXP-2), and small ubiquitin-like modifier–activating enzyme (anti-SAE). Each of these antibodies is referred to by neurologists and rheumatologists by its acronym for convenience,
1
and each is associated with distinct clinical and histopathological features.
2
More than 30 years ago, dermatomyositis was thought to be caused by complement-mediated microangiopathy, but there is evidence that the microvasculopathy and skin and muscle damage associated with dermatomyositis are due primarily to toxicity from pathways mediated by type I . . .