Details

Autor(en) / Beteiligte

• Almeida, Stéphanie Gomes Santos
• Knakcfuss, Fabiana Batalha
• Assis, Lívia Maria
• Sousa, Regina Celia Gonçalves
• Matuck, Tereza Azevedo
• Carvalho, Deise de Boni Monteiro
• Machado, Ricardo Luiz Dantas
• Guimarães, Maria Angelica Arpon Marandino
• Varella, Rafael Brandão

Titel

Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN‐γ +874 A > T and CMV manifestations

Ist Teil von

• International journal of immunogenetics, 2022-12, Vol.49 (6), p.379-383

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Wiley Online Library

Beschreibungen/Notizen

• We investigated the effects of TNF‐α, IFN‐γ, IL‐10 polymorphisms on viral infections (CMV, BKPyV, HHV‐6, EBV) after renal transplantation. IFN‐γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate‐based therapy and graft failure (p = .025). This study underscores the role of IFN‐γ+874 SNP in CMV infection.