Details

Autor(en) / Beteiligte

• Leyva‐López, Nayely
• Gutiérrez‐Grijalva, Erick P.
• Heredia, J. Basilio
• Ramos‐Payan, Rosalio
• Contreras‐Angulo, Laura A.
• Gonzalez‐Galaviz, Jose R.
• Rodriguez‐Anaya, Libia Z.

Titel

Antioxidant potential, cytokines regulation, and inflammation‐related genes expression of phenolic extracts from Mexican oregano

Ist Teil von

• Journal of food biochemistry, 2022-12, Vol.46 (12), p.e14440-n/a

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

Business Source Ultimate【Trial: -2024/12/31】【Remote access available】

Beschreibungen/Notizen

• The Mexican population traditionally uses oregano infusions to treat oxidative and inflammation‐related disorders. Therefore, this study was focused on the examination of the antioxidant capacity and potential against inflammation from three Mexican oregano species (Lippia graveolens [LG], Lippia palmeri [LP], and Hedeoma patens [HP]). The extracts from LG showed a superior total phenolic content. LG, LP, and HP exhibited a higher capacity to inhibit the radical DPPH (up to 90.33 ± 0.25%) and significantly lowered the release of MCP‐1 and IL‐6. At the same time, LG and HP increased the secretion of IL‐10. Extracts from LG, LP, and HP did not significantly diminish the expression of il‐1β or inos, although a slight decrease in inos expression was observed. Our findings support that phenolic extracts from L. graveolens, L. palmeri, and H. patens possess antioxidant and anti‐inflammatory properties and might be potential therapeutic candidates against oxidative and inflammation‐related diseases. Practical applications Oregano species have traditionally been exploited as remedies against inflammatory‐related diseases, namely headaches, asthma, bowel disorders, and rheumatism. This study explored the antioxidant potential of three Mexican oregano species (Lippia graveolens, Lippia palmeri, and Hedeoma patens) and their anti‐inflammatory effects in a murine cell model. Phenolic extracts from oregano showed antioxidant capacity and exerted activity against inflammation by improving anti‐inflammatory cytokines secretion or negatively regulating pro‐inflammatory cytokines. The results of our study demonstrate that the phenolic extracts from these Mexican oregano species have the potential in treating inflammation‐related diseases. Anti‐inflammatory potential of an oregano phenolics extract.