Details

Autor(en) / Beteiligte

• Luna-Muschi, Alessandra
• Noguera, Saidy Vásconez
• Borges, Igor C
• De Paula, Anderson V
• Côrtes, Marina Farrel
• Larocca, Carolina
• Mari, Julia Ferreira
• Guimarães, Lara Silva Pereira
• Torres, Pablo Munoz
• Scaccia, Nazareno
• Villas-Boas, Lucy S
• da Silva, Almir Ribeiro
• Andrade, Pâmela S
• Teixeira, Juliana C
• Escadafal, Camille
• de Oliveira, Vitor Falcão
• Tozetto-Mendoza, Tania R
• Mendes-Correa, Maria Cássia
• Levin, Anna S
• Sabino, Ester C
• Costa, Silvia F

Titel

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Shedding and Predictors of Viral Culture Positivity on Vaccinated Healthcare Workers With Mild Coronavirus Disease 2019

Ist Teil von

• The Journal of infectious diseases, 2022-11, Vol.226 (10), p.1726-1730

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract In this prospective cohort of 30 vaccinated healthcare workers with mild Omicron variant infection, we evaluated viral culture, rapid antigen test (RAT), and real-time reverse-transcription polymerase chain reaction (RT-PCR) of respiratory samples at days 5, 7, 10, and 14. Viral culture was positive in 46% (11/24) and 20% (6/30) of samples at days 5 and 7, respectively. RAT and RT-PCR (Ct ≤35) showed 100% negative predictive value (NPV), with positive predictive values (PPVs) of 32% and 17%, respectively, for predicting viral culture positivity. A lower RT-PCR threshold (Ct ≤24) improved culture prediction (PPV = 39%; NPV = 100%). Vaccinated persons with mild Omicron infection are potentially transmissible up to day 7. RAT and RT-PCR might be useful tools for shortening the isolation period.