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Cu‐catalyzed Synthesis of Quinolines by Dehydrogenative Reaction of 2‐Aminobenzyl Alcohol and Ketones: A Combined Experimental and Computational Study
Ist Teil von
Chemistry, an Asian journal, 2022-11, Vol.17 (22), p.e202200909-n/a
Ort / Verlag
Weinheim: Wiley Subscription Services, Inc
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
Quinoline derivatives are important moieties in bioactive molecules and advanced materials. However, an efficient strategy to synthesize quinoline derivatives remains challenging. Herein, we describe an efficient and practical method for the synthesis of quinolines by Cu‐catalyzed cyclization of 2‐amino benzyl alcohol with ketones (or secondary alcohols) via an acceptorless dehydrogenation pathway. Interestingly, a range of highly functionalized quinolines is prepared in good yields using low catalyst loading under relatively mild conditions. Furthermore, density functional theory (DFT) calculations are carried out to investigate mechanistic insights for the acceptorless dehydrogenation pathway.
Herein, we describe an efficient and practical method for the synthesis of quinolines by Cu‐catalyzed cyclization of 2‐amino benzyl alcohol with ketones (or secondary alcohols) through an acceptorless dehydrogenation pathway.