Details

Autor(en) / Beteiligte

• van Alem, C.M.A.
• Bank, J.R.
• de Vries, D.K.
• Bajema, I.M.
• Mallat, M.J.K.
• de Fijter, J.W.
• Rotmans, J.I.
• van Kooten, C.

Titel

Presence of CD163+ macrophages in DCD kidneys with high DGF reduces the risk for acute cellular rejection in 6 months after kidney transplantation

Ist Teil von

• Transplant immunology, 2022-12, Vol.75, p.101714-101714, Article 101714

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Acute cellular rejection (ACR) occurs in 10% of renal allograft recipients and is characterized by leukocyte infiltration as observed in needle biopsies. ACR onset is subject to several risk factors, including delayed graft function (DGF). As the impact of DGF on the etiology of ACR remains unclear, this study analyzed the association between presence of leukocyte subsets and ACR onset, in DCD kidney biopsies with extensive DGF following transplantation. Immunohistochemical analysis of protocol biopsies taken 10 days after kidney transplantation revealed that patients with high levels of renal CD163+ macrophages have a decreased risk (OR = 0.021, P = 0.008) for ACR in the first 6 months after transplantation. In pre-transplant biopsies of a comparable DCD cohort, with >80% DGF, presence of donor CD163+ macrophages showed no effect on ACR risk. Therefore, leukocyte infiltrate present during the inflammatory response at the time of DGF may contain anti-inflammatory macrophages that exert a protective effect against ACR development. •Infiltrating leukocyte subsets characterize day 10 protocol biopsies of DCD kidney transplants.•Increased numbers of CD163 macrophages in these day 10 biopsies reduce the risk for subsequent acute cellular rejection•Presence of donor CD163 macrophages in DCD pre-transplant renal biopsies does not predict risk for acute cellular rejection