Details

Autor(en) / Beteiligte

• Devaraj, Sridevi
• Rajapakshe, Deepthi
• Ye, Wen
• Minard, Charles G
• Guffey, Danielle
• Molleston, Jean P
• Bass, Lee M
• Karpen, Saul J
• Kamath, Binita M
• Sundaram, Shikha S
• Horslen, Simon P
• Bezerra, Jorge A
• Magee, John C
• Merion, Robert M
• Shneider, Benjamin L
• Alonso, Estella
• Kelly, Susan
• Riordan, Mary
• Melin-Aldana, Hector
• Miethke, Alexander
• Denlinger, Julie
• Chapman, Erin
• Feldman, Amy
• Mack, Cara
• Narkewicz, Michael
• Suchy, Frederick
• Van Hove, Johan
• Kauma, Mikaela
• Kocher, Kendra
• Steinbeiss, Matthew
• Lovell, Mark
• Loomes, Kathleen M
• Piccoli, David
• Rand, Elizabeth
• Russo, Pierre
• Spinner, Nancy
• Erlichman, Jessi
• Pakstis, Dina
• King, Sakya
• Squires, Robert
• Sindhi, Rakesh
• Venkat, Veena
• Bukauskas, Kathy
• Haberstroh, Lori
• Rosenthal, Philip
• Bull, Laura
• Curry, Joanna
• Langlois, Camille
• Teckman, Jeffery
• Patel, Shraddha
• Cerkoski, Jacqueline
• Bozic, Molly
• Subbarao, Girish
• Klipsch, Ann
• Sawyers, Cindy
• Murray, Karen
• Hsu, Evelyn
• Finn, Laura
• Ng, Vicky
• Quammie, Claudia
• Putra, Juan
• Guthery, Stephen
• Jensen, Kyle
• Rutherford, Ann
• Lowichik, Amy
• Book, Linda
• Meyers, Rebecka
• Hall, Tyler
• Wang, Kasper S
• Michail, Sonia
• Thomas, Danny
• Goodhue, Catherine
• Kohli, Rohit
• Wang, Larry
• Thomas, Daniel
• Gupta, Nitika
• Romero, Rene
• Vos, Miriam B
• Berauer, John-Paul
• McFall, Jeanette
• Harpavat, Sanjiv
• Hertel, Paula
• Leung, Daniel
• Tessier, Mary
• Cavallo, Laurel
• Olvera, Diego
• Banks, Christina
• Tsai, Cynthia
• Thompson, Richard
• Doo, Edward
• Hoofnagle, Jay
• Sherker, Averell
• Torrance, Rebecca
• Magee, John
• Merion, Robert
• Spino, Cathie

Titel

Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease

Ist Teil von

• Hepatology (Baltimore, Md.), 2023-02, Vol.77 (2), p.530-n/a

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Detailed investigation of the biological pathways leading to hepatic fibrosis and identification of liver fibrosis biomarkers may facilitate early interventions for pediatric cholestasis. A targeted enzyme-linked immunosorbent assay-based panel of nine biomarkers (lysyl oxidase, tissue inhibitor matrix metalloproteinase (MMP) 1, connective tissue growth factor [CTGF], IL-8, endoglin, periostin, Mac-2-binding protein, MMP-3, and MMP-7) was examined in children with biliary atresia (BA; n = 187), alpha-1 antitrypsin deficiency (A1AT; n = 78), and Alagille syndrome (ALGS; n = 65) and correlated with liver stiffness (LSM) and biochemical measures of liver disease. Median age and LSM were 9 years and 9.5 kPa. After adjusting for covariates, there were positive correlations among LSM and endoglin ( p = 0.04) and IL-8 ( p < 0.001) and MMP-7 ( p < 0.001) in participants with BA. The best prediction model for LSM in BA using clinical and lab measurements had an R2 = 0.437; adding IL-8 and MMP-7 improved R2 to 0.523 and 0.526 (both p < 0.0001). In participants with A1AT, CTGF and LSM were negatively correlated ( p = 0.004); adding CTGF to an LSM prediction model improved R2 from 0.524 to 0.577 ( p = 0.0033). Biomarkers did not correlate with LSM in ALGS. A significant number of biomarker/lab correlations were found in participants with BA but not those with A1AT or ALGS. Endoglin, IL-8, and MMP-7 significantly correlate with increased LSM in children with BA, whereas CTGF inversely correlates with LSM in participants with A1AT; these biomarkers appear to enhance prediction of LSM beyond clinical tests. Future disease-specific investigations of change in these biomarkers over time and as predictors of clinical outcomes will be important.