Details

Autor(en) / Beteiligte

• Mitsuda, Naomi
• Eitoku, Masamitsu
• Yamasaki, Keiko
• J-P, Naw Awn
• Fujieda, Mikiya
• Suganuma, Narufumi
• Kamijima, Michihiro
• Yamazaki, Shin
• Ohya, Yukihiro
• Kishi, Reiko
• Yaegashi, Nobuo
• Hashimoto, Koichi
• Mori, Chisato
• Ito, Shuichi
• Yamagata, Zentaro
• Inadera, Hidekuni
• Nakayama, Takeo
• Iso, Hiroyasu
• Shima, Masayuki
• Nakamura, Hiroshige
• Kusuhara, Koichi
• Katoh, Takahiko

Titel

Association between the ratio of placental weight to birthweight and the risk of neurodevelopmental delay in 3-year-Olds: The Japan environment and Children's study

Ist Teil von

• Placenta (Eastbourne), 2022-10, Vol.128, p.49-56

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The ratio of placental weight to birthweight (PW/BW ratio) is well known as a simple indicator of the prenatal intrauterine environment and placental functioning. We assessed the impact of PW/BW ratio on the risk of neurodevelopmental delay in 3-year-olds. We used data of 71 205 mother–child pairs enrolled in the Japan Environment and Children's Study. Low PW/BW ratio was defined as a PW/BW ratio below the 10th percentile of the study population, high PW/BW ratio was defined as above the 90th percentile, and normal PW/BW ratio was defined as between the low and high PW/BW ratio. Neurodevelopment was assessed using the Japanese translation of the Ages and Stages Questionnaires, third edition. Associations between PW/BW ratio and risk of developmental delay were examined using multivariable models. Compared with boys in the normal PW/BW group, boys in the high PW/BW group had higher risk for developmental delays in all domains except fine motor skills (communication: adjusted risk ratio [aRR], 1.17; 95% confidence interval [CI], 1.04–1.33; gross motor skills: aRR, 1.28; 95% CI, 1.13–1.46; problem solving: aRR, 1.20; 95% CI, 1.09–1.31; personal–social: aRR, 1.26; 95% CI, 1.10–1.43), and boys in the low PW/BW group also had higher risk for developmental delays in some domains. For girls, there was almost no association between PW/BW ratio and developmental delay. An unbalanced PW/BW ratio, especially high PW/BW ratio, might indicate intrauterine suboptimality, which affects child neurodevelopment in a sex-specific manner. •Placental weight/birthweight (PW/BW) ratio is known to reflect placental function.•Association between PW/BW ratio and risk of neurodevelopmental delay was examined.•High PW/BW ratio was associated with increased risk of developmental delay in boys.•Unbalanced PW/BW ratio may indicate intrauterine suboptimality.