Details

Autor(en) / Beteiligte

• Díaz-García, Judith
• Gómez, Ana
• Machado, Marina
• Alcalá, Luis
• Reigadas, Elena
• Sánchez-Carrillo, Carlos
• Pérez-Ayala, Ana
• Gómez-García De La Pedrosa, Elia
• González-Romo, Fernando
• Cuétara, María Soledad
• García-Esteban, Coral
• Quiles-Melero, Inmaculada
• Zurita, Nelly Daniela
• Muñoz-Algarra, María
• Durán-Valle, María Teresa
• Sánchez-García, Aída
• Muñoz, Patricia
• Escribano, Pilar
• Guinea, Jesús
• Mesquida, Aina
• Muñoz, Rosaura Pérez
• del Carmen Vera González, María
• Romo, Fernando González
• Merino-Amador, Paloma
• Clemente, Oscar Manuel Muñoz
• Berenguer, Víctor Antón
• Lobato, Oscar Cuevas
• Bernal, Guadalupe
• Zurita, Nelly
• Cobos, Ainhoa Gutiérrez
• Romero, Isabel Sánchez
• Delgado, Florinda San Juan
• Romero, Yolanda Gil
• Torres, Arturo Manuel Fraile

Titel

Blood and intra-abdominal Candida spp. from a multicentre study conducted in Madrid using EUCAST: emergence of fluconazole resistance in Candida parapsilosis , low echinocandin resistance and absence of Candida auris

Ist Teil von

• Journal of antimicrobial chemotherapy, 2022-10, Vol.77 (11), p.3102-3109

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Objectives We prospectively monitored the epidemiology and antifungal susceptibility of Candida spp. from blood cultures and intra-abdominal samples in patients admitted to hospitals in the Madrid area. Methods Between 2019 and 2021, we prospectively collected incident isolates [one per species, patient and compartment (blood cultures versus intra-abdominal samples)] from patients admitted to any of 16 hospitals located in Madrid. We studied the antifungal susceptibilities to amphotericin B, triazoles, micafungin, anidulafungin and ibrexafungerp following the EUCAST E.Def 7.3.2 procedure. Results A total of 2107 Candida spp. isolates (1895 patients) from blood cultures (51.7%) and intra-abdominal samples were collected. Candida albicans, the Candida glabrata complex, the Candida parapsilosis complex, Candida tropicalis and Candida krusei accounted for 96.9% of the isolates; in contrast, Candida auris was undetected. Fluconazole resistance in Candida spp. was higher in blood cultures than in intra-abdominal samples (9.1% versus 8.2%; P > 0.05), especially for the C. parapsilosis complex (16.6% versus 3.6%, P < 0.05), whereas echinocandin resistance tended to be lower in blood cultures (0.5% versus 1.0%; P > 0.05). Resistance rates have risen, particularly for fluconazole in blood culture isolates, which increased sharply in 2021. Ibrexafungerp showed in vitro activity against most isolates. Species distributions and resistance rates varied among hospitals. Conclusions Whereas no C. auris isolates were detected, fluconazole-resistant C. parapsilosis isolates have been spreading across the region and this has pulled up the rate of fluconazole resistance. In contrast, the rate of echinocandin resistance continues to be low.