Details

Autor(en) / Beteiligte

• Ayano, Masahiro
• Kimoto, Yasutaka
• Mitoma, Hiroki
• Akahoshi, Mitsuteru
• Ono, Nobuyuki
• Arinobu, Yojiro
• Akashi, Koichi
• Horiuchi, Takahiko
• Niiro, Hiroaki

Titel

Safety and efficacy of switching immunosuppressive drugs for maintenance treatment in patients with systemic lupus erythematosus: A retrospective cohort study

Ist Teil von

• Modern rheumatology, 2023-08, Vol.33 (5), p.961-967

Ort / Verlag

UK: Oxford University Press

Erscheinungsjahr

2023

Beschreibungen/Notizen

• ABSTRACT Objectives We aim to clarify the efficacy and safety of switching immunosuppressive drugs and to identify the predictive factors for treatment failure after switching in patients with systemic lupus erythematosus (SLE). Methods We retrospectively evaluated patients with SLE who switched immunosuppressive drugs for any reason in our hospital between 2015 and 2020. The efficacy endpoints were the change in SLE Disease Activity Index 2000 score, prednisolone dose, and disease status over 12 months, as well as treatment continuation rates. The safety endpoint was the frequency of adverse events over 1 year before and after switching. Cox hazard regression analyses were used to identify the predictive factors for treatment failure. Results Thirty-nine patients (age, 41.5 ± 12.6 years; 35 women and 4 men) were analysed. The SLE Disease Activity Index score and prednisolone dose were significantly reduced after switching, with few disease exacerbations over 12 months. The 1- and 2-year continuation rates were 71.4% and 62.3%, respectively. The frequency of adverse events was similar in the year before and after switching the drug. Drug switching due to inadequate efficacy was a predictive factor of less likely treatment failure. Conclusions Immunosuppressive drug switching led to reduced disease activity and decreased glucocorticoid dose without disease exacerbations and severe adverse events.