Details

Autor(en) / Beteiligte

• Damle, V.G.
• Wu, K.
• Arouri, D.J.
• Schirhagl, R.

Titel

Detecting free radicals post viral infections

Ist Teil von

• Free radical biology & medicine, 2022-10, Vol.191, p.8-23

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

ScienceDirect Journals (5 years ago - present)

Beschreibungen/Notizen

• Free radical generation plays a key role in viral infections. While free radicals have an antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies greatly for different types of viruses as well as different radical species. In some cases, radical generation contributes to the defense against the viruses and thus reduces the viral load. In other cases, radical generation induces mutations or damages the host tissue and can increase the viral load. This has led to antioxidants being used to treat viral infections. Here we discuss the roles that radicals play in virus pathology. Furthermore, we critically review methods that facilitate the detection of free radicals in vivo or in vitro in viral infections. [Display omitted] •Free radical generation plays a role in viral infection.•The exact mechanisms as well as whether free radical generation has a positive or negative effect vary per virus.•Several methods detect free radicals in cells including probes that react to radicals, detecting damage or cell response.