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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury
Ist Teil von
Chemical communications (Cambridge, England), 2022-09, Vol.58 (72), p.152-155
Ort / Verlag
Cambridge: Royal Society of Chemistry
Erscheinungsjahr
2022
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (
GA-Vis
) was developed. With the aid of
GA-Vis
, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish.
GA-Vis
was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.
The first Golgi-targeted fluorescent rotor (
GA-Vis
) to visualize Golgi viscosity for early diagnosis of alcoholic liver injury at the subcellular level.