Chemical communications (Cambridge, England), 2022-09, Vol.58 (72), p.152-155
2022
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Details
- Autor(en) / Beteiligte
- Titel
- A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury
- Ist Teil von
- Chemical communications (Cambridge, England), 2022-09, Vol.58 (72), p.152-155
- Ort / Verlag
- Cambridge: Royal Society of Chemistry
- Erscheinungsjahr
- 2022
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor ( GA-Vis ) was developed. With the aid of GA-Vis , the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury. The first Golgi-targeted fluorescent rotor ( GA-Vis ) to visualize Golgi viscosity for early diagnosis of alcoholic liver injury at the subcellular level.