Details

Autor(en) / Beteiligte

• Xiao, Hui‐Ping
• Hao, Ya‐Shuai
• Li, Xin‐Xiong
• Xu, Peng
• Huang, Ming‐Dong
• Zheng, Shou‐Tian

Titel

A Water‐Soluble Antimony‐Rich Polyoxometalate with Broad‐Spectrum Antitumor Activities

Ist Teil von

• Angewandte Chemie International Edition, 2022-10, Vol.61 (41), p.e202210019-n/a

Auflage

International ed. in English

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein, a giant Sb‐rich polyoxometalate (POM) {Sb21Tb7W56} is reported, which contains the largest number of Sb atoms in a POM so far. The Sb‐rich POM has many interesting structural features and is a rare example of a soluble and water‐stable giant POM. Biomedical studies indicate that the Sb‐rich POM exhibits broad‐spectrum antitumor activity against various cancer cell lines by reactivating the P53‐dependent apoptotic processes and disrupting the mitochondrial membrane. In addition, this Sb‐rich POM was capable of suppressing the growth and metastasis of a breast cancer in vivo. This work demonstrates that Sb‐rich POMs are promising candidates for the development of new anticancer drugs. A novel soluble and water‐stable giant Sb‐rich polyoxometalate (POM) has been developed, which shows the largest Sb−Ln−W cluster and has the greatest number of Sb centers in a cluster yet found in POM chemistry. Importantly, the Sb‐rich POM can exhibit broad‐spectrum antitumor and anti‐metastatic activities in vitro and in vivo without causing adverse effects, making it a promising candidate for a antitumor agent.