Details

Autor(en) / Beteiligte

• Saraiva, Matheus Morais
• Campelo, Matheus da Silva
• Câmara Neto, João Francisco
• Lima, Ana Beatriz Nogueira
• Silva, George de Almeida
• Dias, Andre Tavares de Freitas Figueredo
• Ricardo, Nágila Maria Pontes Silva
• Kaplan, David L.
• Ribeiro, Maria Elenir Nobre Pinho

Titel

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Ist Teil von

• Journal of biomedical materials research. Part B, Applied biomaterials, 2023-01, Vol.111 (1), p.220-233

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA‐based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical–chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing. Different SA/PVA ratios provide formulations with versatile properties for various applications. Drugs loaded in SA/PVA‐based films improve wound healing outcomes. Crosslinking improved physicochemical and biological properties of SA/PVA‐based films.