Details

Autor(en) / Beteiligte

• Qian, Xin
• He, Siyao
• Shen, Xiaoxia
• Shi, Na
• Gong, Qiuhong
• An, Yali
• Chen, Yanyan
• Wang, Jinping
• Li, Guangwei

Titel

Circulating levels of GDF-15 for predicting cardiovascular and cancer morbidity and mortality in type 2 diabetes: Findings from Da Qing IGT and Diabetes Study

Ist Teil von

• Diabetes & metabolism, 2022-11, Vol.48 (6), p.101380-101380, Article 101380

Ort / Verlag

Elsevier Masson SAS

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •People with type 2 diabetes have metabolic disorders.•If GDF-15 related to the risk of CVD and cancer in people with diabetes remains unclear.•GDF-15 levels were related to increased risk of CVD and cancer morbidity and mortality.•GDF-15 is a marker for the dual risk of CVD and cancer in people with diabetes. To investigate the relationship between circulating growth differentiation factor (GDF-15) levels and the risk of cardiovascular disease and cancer in people with diabetes. Totally, 510 participants with type 2 diabetes were enrolled from the long-term follow-up of the Da Qing Impaired Glucose Tolerance (IGT) and Diabetes Study (2006–2009). Plasma GDF-15 levels were assessed. Outcomes of cardiovascular events, cancer, and related death were followed up until 2016. Over a 7.5-year follow-up period, 143 (28.0%) of the participants died, and 155 and 56 experienced cardiovascular events and cancer respectively. Multivariable Cox analysis showed that higher circulating GDF-15 levels were significantly associated with the increased risk of cardiovascular and cancer death. The HRs after adjustment of traditional confounders were 1.90 (95%CI 1.31–2.74) and 2.50 (95%CI 1.34–4.67) respectively for an increase in one unit of loge transformed GDF-15 (pg/ml). The cause-specific hazard model analysis further confirmed the results after adjusting the same confounders. In addition, the higher GDF-15 levels were also significantly associated with the increased risk of cardiovascular events (HR=1.35, 95%CI: 1.04–1.76) and cancer (HR=1.62, 95%CI 1.06–2.47). Elevated circulating levels of GDF-15 predicted a significant increase in the dual risk of cancer and cardiovascular diseases in Chinese people with type 2 diabetes. Thus, it may be a potential predictor of these outcomes in people with diabetes.