Details

Autor(en) / Beteiligte

• Gao, HW
• Sun, P-L

Titel

Pulmonary sialadenoma papilliferum and its mimics: what you need to know

Ist Teil von

• Histopathology, 2022-12, Vol.81 (6), p.715-723

Ort / Verlag

Oxford: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Pumonary salivary gland‐type tumours (SGT) represent a small but distinct group of primary lung neoplasms. These types of tumours originate from the submucosal bronchial glands of the tracheobronchial tree. Pulmonary SGTs differ greatly in the incidence of individual tumours from salivary gland tumours of the head and neck. Additionally, the vast majority of pulmonary SGT are malignant. Recently, pathological diagnosis has significantly improved with the application of molecular diagnostic technologies. However, the current knowledge of benign SGTs is limited; moreover, tumour diversity and overlapping morphological features of SGT represent diagnostic challenges such as correct tumour categorisation and their accurate differentiation from malignant lesions. Compounding this inherent difficulty has been the recent introduction of new variants, including sialadenoma papilliferum (SP). Pulmonary SP is very rare, with limited reports available, and most of the initial diagnoses rendered so far were incorrect, resulting in inappropriate treatment. Several cases of SP have recently been reported. This review will serve to update practicing pathologists on the morphology, immunophenotype and molecular characteristics of SP and its mimics. PSP is a rare benign salivary gland‐type tumor that can mimic other bronchopulmonary tumors microscopically, with limited reports available, and most of the initial diagnoses rendered so far were incorrect, resulting in inappropriate treatment. PSP is usually located in the main or lobar bronchus and shows characteristic exophytic proliferation of papillary stratified squamous epithelium with contiguous endophytic ductal proliferation underneath. SP expresses SOX10, and nearly half of the cases present BRAF V600E mutation.