Details

Autor(en) / Beteiligte

• Gomez-Verjan, J.C.
• Esparza-Aguilar, M.
• Martín-Martín, V.
• Salazar-Pérez, C.
• Cadena-Trejo, C.
• Gutiérrez-Robledo, L.M.
• Arroyo, P.

Titel

DNA methylation profile of a rural cohort exposed to early-adversity and malnutrition: An exploratory analysis

Ist Teil von

• Experimental gerontology, 2022-10, Vol.167, p.111899-111899, Article 111899

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Barker's hypothesis affirms that undernourishment in early-life induces metabolic reprogramming that compromises organism functions later in life, leading to age-related diseases. We are exposed to environmental and social conditions that impact our life trajectories, leading to ageing phenotypes as we grow. Epigenetic mechanisms constitute the link between both external stimuli and genetic programming. Studies have focused on describing the effect of early adverse events such as trauma, famines, or childhood labor on epigenetic markers in adulthood and the elderly. However, we lack information on epigenetic programming in individuals born in rural communities from underdeveloped countries, exposed to negative influences during fetal and postnatal development, particularly chronic malnutrition. Hence, in this exploratory analysis, we characterize the epigenome of individuals and some parents from Tlaltizapan (a rural community in Mexico originally studied almost 50 years ago) and collect anthropometric data on growth and development, as well on the living conditions of the families. Our results help build a biological hypothesis indicating that most of the epigenetic age measures of the subjects are significantly different among them. Interestingly, the most affected methylated regions correspond to pathways involved in neuronal system development, reproductive behaviour, learning and memory regulation. •In 1966 Cravioto et al. recruited information of children born in Tlaltizapan exposed to malnutrition.•52 years from we were able to track down members of the original cohort.•We obtained biochemical clinical variables and the epigenome.•Altered pattern of genes related to behaviour and biological regulation