Details

Autor(en) / Beteiligte

• Su, Guo-Zhu
• Li, Mi
• Wang, Xiao-Jing
• Wang, Ru-Bing
• Ma, Shuang-Gang
• Zhang, Dan
• Wang, Xiao-Liang
• Li, Li
• Liu, Yun-Bao
• Qu, Jing
• Li, Yu-Huan
• Li, Yong
• Yu, Shi-Shan

Titel

Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect

Ist Teil von

• Phytochemistry (Oxford), 2022-10, Vol.202, p.113323-113323, Article 113323

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii. Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-crystal X-ray diffraction analysis. Illisimonone A showed potential antiviral activity against the Coxsackie B3 virus, with an IC50 value of 3.70 μM. Illisimonin B and henrylactone A showed potential neuroprotective effects against oxygen-glucose deprivation induced cell injury in SK-N-SH cells, with survival rates of 57.6%, 58.0%, respectively. Seven undescribed compounds, together with five known compounds were isolated from Illicium simonsii Maxim. Their antiviral and neuroprotective activities were evaluated. [Display omitted] •Seven undescribed compounds were isolated from the fruits of Illicium simonsii.•The absolute configuration of undescribed compounds were determined by single-crystal X-ray diffraction analysis, ECD calculation, and a modified Mosher's method.