Details

Autor(en) / Beteiligte

• Xu, Xin-Ming
• Li, Wenzhong
• Li, Qiwei
• Chen, Sen
• Zhang, Xuesi
• Yang, Bin
• Wang, Wei-Li

Titel

Manganese( iii )-promoted highly stereoselective phosphorylation of acyclic tertiary enamides to synthesize E -selective β-phosphoryl enamides

Ist Teil von

• Organic & biomolecular chemistry, 2022-07, Vol.20 (28), p.5566-5574

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A concise manganese( iii )-promoted stereoselective β-phosphorylation of acyclic tertiary enamides and diverse H-phosphine oxides was achieved. This reaction proceeds with absolute E -selectivity in contrast to Z -selectivity obtained in other previous works and affords various E -selective β-phosphorylated tertiary enamides in high efficiency. To the best of our knowledge, this is the first case of E -selective β-phosphorylation of tertiary enamides through C–H functionalization. In addition, the method features broad substrate scope, good functional group compatibility and efficient scale-up.