Details

Autor(en) / Beteiligte

• Xian, Peng-Jie
• Liu, Shu-Zhi
• Wang, Wen-Jing
• Yang, Sheng-Xiang
• Feng, Zhang
• Yang, Xiao-Long

Titel

Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

Ist Teil von

• Phytochemistry (Oxford), 2022-10, Vol.202, p.113303-113303, Article 113303

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2022

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 μg/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 μg/mL and 3.13 μg/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 μg/mL. Fifteen specialised products, including seven undescribed structures, were obtained from Emericella sp. XL029 isolated from leaves of Panax notoginseng using the OSMAC strategy. Their antimicrobial activities against eight clinically important drug-resistant bacterial strains and seven species of agricultural pathogenic fungi were evaluated. [Display omitted] •Seven undescribed structures were isolated from Emericella sp. XL029.•Their absolute configurations were determined by X-ray crystallography or ECD technique.•Quiannulatic acid displayed significant antibacterial activity.•5-alkenylresorcinol exhibited significant antifungal activity.