Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Importantly, by developing a novel strategy to align distantly related genomes, the authors could identify syntenic regulatory elements shared between mouse and zebrafish to demonstrate that H3K27ac ensembles are likely a conserved feature of vertebrate genome regulation. [...]the efforts of DANIO-CODE to provide an exhaustive annotation for the zebrafish genome can facilitate the identification of unique, conserved, and developmentally relevant genomic regulatory features. More comprehensive incorporation of single-cell molecular approaches is also necessary, as this initial dAnIO-CODE effort relies largely on whole embryos, potentially confounding interpretation of the current work. Since few zebrafish cell lines are available, further technical advances in molecular analysis at single-cell resolution and their application to zebrafish embryos will be essential for future DANIO-CODE phases. [...]the ENCODE project, along with parallel efforts for model organisms, enjoyed generous large-scale funding efforts from the National Institutes of Health.