Details

Autor(en) / Beteiligte

• Meneses, Gdayllon Cavalcante
• Carvalho Gomes, Pedro Eduardo Andrade
• Galdino, Gabriela Studart
• Bezerra, Gabriela Freire
• Souza Santos, Ranieri Sales
• Martins, Alice Maria Costa
• Silva Junior, Geraldo Bezerra
• Libório, Alexandre Braga
• Pires Neto, Roberto da Justa
• Daher, Elizabeth De Francesco

Titel

Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease)

Ist Teil von

• Tropical medicine & international health, 2022-08, Vol.27 (8), p.727-734

Ort / Verlag

Oxford: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Objective To investigate the prediction ability of vascular injury biomarkers for haemodialysis requirement in patients with severe leptospirosis. Methods Prospective study with severe leptospirosis patients hospitalised in Fortaleza, Brazil. Blood samples were collected hospital admission to quantify vascular injury biomarkers: syndecan‐1, ICAM‐1, VCAM‐1, angiopoietin‐2 and FGF‐23. Two groups were evaluated according to haemodialysis requirement during hospital stay. Results Twenty‐seven patients were included, with a mean age of 39 ± 18 years. 88.9% were males. 53.8% needed haemodialysis and presented higher levels on hospital admission of syndecan‐1 (572 [300–811] vs. 263 [106–421] ng/ml; p = 0.03), angiopoietin‐2 (1.52 [0.72–2.72] vs. 0.63 [0.4–1.38] ng/ml; p = 0.01), and FGF‐23 (291 [56–2031] vs. 10 [10–806] pg/ml; p = 0.021). Syndecan‐1 showed significant correlation with creatinine (r = 0.546; p = 0.05) and total bilirubin levels (r = 0.534; p = 0.013) on hospital admission. Angiopoietin‐2 showed significant correlation with creatinine levels (r = 0.513; p = 0.009) on hospital admission and with number of haemodialysis sessions (r = 0.406; p = 0.049). No significant correlation was found with FGF‐23. Regarding prognostic performance, combined syndecan‐1 and angiopoietin‐2 levels had a better ability to predict haemodialysis need in patients with severe leptospirosis (AUC‐ROC = 0.744 [95% CI: 0.545–0.943] p = 0.035). Conclusion Syndecan‐1 and angiopoietin‐2 were associated with haemodialysis need in patients with severe leptospirosis and may be useful to improve therapeutic approach and reduce mortality.