Details

Autor(en) / Beteiligte

• Pala, Laura
• De Pas, Tommaso
• Catania, Chiara
• Giaccone, Giuseppe
• Mantovani, Alberto
• Minucci, Saverio
• Viale, Giuseppe
• Gelber, Richard D.
• Conforti, Fabio

Titel

Sex and cancer immunotherapy: Current understanding and challenges

Ist Teil von

• Cancer cell, 2022-07, Vol.40 (7), p.695-700

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Recent evidence highlights patients’ sex relevance in antitumor immune response through a complex interaction—among hormones, genes, behaviors, and the microbiome—that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors. Recent evidence highlights patients’ sex relevance in antitumor immune response through a complex interaction—among hormones, genes, behaviors, and the microbiome—that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.