Details

Autor(en) / Beteiligte

• Zhang, Ya-Hui
• Li, Lei
• Li, Ya-Qi
• Luo, Jia-Hua
• Li, Wan
• Li, Long-Fei
• Zheng, Cai-Juan
• Cao, Fei

Titel

Oxalierpenes A and B, Unusual Indole-Diterpenoid Derivatives with Antiviral Activity from a Marine-Derived Strain of the Fungus Penicillium oxalicum

Ist Teil von

• Journal of natural products (Washington, D.C.), 2022-07, Vol.85 (7), p.1880-1885

Ort / Verlag

American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Oxalierpenes A and B (1 and 2), two unusual indole-diterpenoid derivatives, were obtained from the marine-derived fungus Penicillium oxalicum. The absolute configurations of 1 and 2 were elucidated by calculated TDDFT ECD and DP4plus methods. Oxalierpene A (1) represents the first indole-diterpenoid derivative with a five-membered ring of 4-hydroxy-5,5-dimethyldihydrofuran-3-one as a side chain. Oxalierpene B (2) has a unique 6/5/6/5/5/6/6/5/5 ring system. Compounds 1 and 2 showed antiviral activity against the H1N1 virus and respiratory syncytial virus (RSV), with IC50 values ranging from 2.8 to 9.4 μM.