Details

Autor(en) / Beteiligte

• Nezhad Shamohammadi, Fatemeh
• Yazdanifar, Mahboubeh
• Oraei, Mona
• Kazemi, Mohammad H
• Roohi, Azam
• Mahya Shariat razavi, Seyedeh
• Rezaei, Farhad
• Parvizpour, Farzad
• Karamlou, Yalda
• Namdari, Haideh

Titel

Controversial role of γδ T cells in pancreatic cancer

Ist Teil von

• International immunopharmacology, 2022-07, Vol.108, p.108895-108895, Article 108895

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• •Depending on the local micro milieu, γδ T cells can differentiate into tumor promoting or suppressing cells.•Presence of γδ T cells in the pancreatic tumor is beneficial to tumor progression.•Various strategies have been proposed to increase the cytotoxicity of γδ T cells in pancreatic cancer. γδ T cells are rare lymphocytes with cogent impact on immune responses. These cells are one of the earliest cells to be recruited in the sites of infection or tumors and play a critical role in coordinating innate and adaptive immune responses. The anti-tumor activity of γδ T cells have been numerously reported; nonetheless, there is controversy among published studies regarding their anti-tumor vs pro-tumor effect- especially in pancreatic cancer. A myriad of studies has confirmed that activated γδ T cells can potently lyse a broad variety of solid tumors and leukemia/lymphoma cells and produce an array of cytokines; however, early γδ T cell-based clinical trials did not lead to optimal efficacy, despite acceptable safety. Depending on the local micromilieu, γδ T cells can differentiate into tumor promoting or suppressing cells such as Th1-, Th2-, or Th17-like cells and produce prototypical cytokines such as interferon-γ (IFNγ) and interleukin (IL)-4/-10, IL-9, or IL-17. In an abstruse tumor such as pancreatic cancer- also known as immunologically cold tumor- γδ T cells are more likely to switch to their immunosuppressive phenotype. In this review we will adduce the accumulated knowledge on these two controversial aspects of γδ T cells in cancers- with a focus on solid tumors and pancreatic cancer. In addition, we propose strategies for enhancing the anti-tumor function of γδ T cells in cancers and discuss the potential future directions.