Vaccine, 2022-07, Vol.40 (32), p.4312-4317
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Strength and durability of antibody responses to BNT162b2 and CoronaVac
- Ist Teil von
- Vaccine, 2022-07, Vol.40 (32), p.4312-4317
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2022
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- We studied 2780 adults in Hong Kong who received CoronaVac inactivated virus vaccine (Sinovac) and BNT162b2 mRNA vaccine (“Comirnaty”, BioNTech/Fosun Pharma). We compared rates of antibody waning over time using an enzyme-linked immunosorbent assay for spike receptor binding domain and a surrogate virus neutralization test. We found stronger and more durable antibody responses to two doses of the mRNA vaccine, and slightly stronger initial antibody responses to each vaccine in younger adults and women. The weaker and less durable responses following CoronaVac support earlier provision of third doses to persons who previously received two doses of this vaccine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2022.05.033Titel-ID: cdi_proquest_miscellaneous_2676926251
- Format
- –
- Schlagworte
- Adult, Adults, Age groups, Antibodies, Antibodies, Viral, Antibody Formation, BNT162 Vaccine, Coronaviruses, COVID-19, COVID-19 Vaccines, Durability, Enzyme-linked immunosorbent assay, Female, Humans, Infections, mRNA, mRNA Vaccines, Neutralization, Pharmaceuticals, Severe acute respiratory syndrome coronavirus 2, Vaccination, Vaccines, Vaccines, Synthetic, Viruses