Details

Autor(en) / Beteiligte

• Wang, Jia
• Gong, Ruining
• Zhao, Chenyang
• Lei, Ke
• Sun, Xiaoyuan
• Ren, He

Titel

Human FOXP3 and tumour microenvironment

Ist Teil von

• Immunology, 2023-02, Vol.168 (2), p.248-255

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of Tregs. FOXP3 was originally thought to be a Tregs‐specific expression molecule, and recent studies have found that FOXP3 is expressed in a variety of tumours with inconsistent functional roles. This review summarizes the recent progress of infiltrating Treg‐FOXP3 and tumour‐FOXP3 in TME, discusses the communication mechanism between FOXP3+ cells and effector T cells in TME, the relationship between FOXP3 and clinical prognosis, and the potential of FOXP3‐targeted therapy. Here, we review the research progress of Treg‐FOXP3 and tumor‐FOXP3 in TME, including how Foxp3 controls the function of Tregs, and the role of FOXP3+ cells in TME.