Details

Autor(en) / Beteiligte

• Sugawara, Norio
• Adachi, Naoto
• Kubota, Yukihisa
• Watanabe, Yoichiro
• Miki, Kazuhira
• Azekawa, Takaharu
• Edagawa, Koji
• Katsumoto, Eiichi
• Hongo, Seiji
• Goto, Eiichiro
• Ueda, Hitoshi
• Kato, Masaki
• Yoshimura, Reiji
• Nakagawa, Atsuo
• Kikuchi, Toshiaki
• Tsuboi, Takashi
• Watanabe, Koichiro
• Shimoda, Kazutaka
• Yasui-Furukori, Norio

Titel

Determinants of three-year clinical outcomes in real-world outpatients with bipolar disorder: The multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics (MUSUBI)

Ist Teil von

• Journal of psychiatric research, 2022-07, Vol.151, p.683-692

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• There is limited evidence regarding predictors of long-term clinical outcomes in patients with bipolar disorder (BD). The objective of this study was to describe 3-year clinical outcomes and identify their predictors from participants in the multicenter treatment survey for BD in psychiatric outpatient clinics (MUSUBI). The MUSUBI was a naturalistic study investigating patients with BD in real-world clinical practice. Our study extracted data regarding 1647 outpatients with BD from 2016, 2017, and 2019 as baseline, 1-year, and 3-year assessments. As clinical outcomes, we assessed the presence of time ill (depressive and manic) during the 1 year prior to the 3-year assessment and durable remission (53 weeks or more) prior to the 3-year assessment. Participants with durable remission prior to the 3-year assessment had significant associations with diagnosis of a personality disorder and duration of continuous remission at baseline. Regarding the presence of depressive symptoms during the 1 year prior to the 3-year assessment, work status, Global Assessment of Functioning (GAF) scores, suicidal ideation, and duration of continuous remission at baseline had significant associations with this outcome. At the 3-year assessment, 19.3% of participants (318/1647) achieved durable remission, while 47.5% of them (782/1647) were not remitted. Our findings can help clinicians predict the illness course of BD by understanding demographic and clinical characteristics.