Details

Autor(en) / Beteiligte

• Walker, Richard J. B.
• Look Hong, Nicole J.
• Moncrieff, Marc
• van Akkooi, Alexander C. J.
• Jost, Evan
• Nessim, Carolyn
• van Houdt, Winan J.
• Stahlie, Emma H. A.
• Seo, Chanhee
• Quan, May Lynn
• McKinnon, J. Gregory
• Wright, Frances C.
• Mavros, Michail N.

Titel

Predictors of Sentinel Lymph Node Metastasis in Patients with Thin Melanoma: An International Multi-institutional Collaboration

Ist Teil von

• Annals of surgical oncology, 2022-10, Vol.29 (11), p.7010-7017

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Background Consideration of sentinel lymph node biopsy (SLNB) is recommended for patients with T1b melanomas and T1a melanomas with high-risk features; however, the proportion of patients with actionable results is low. We aimed to identify factors predicting SLNB positivity in T1 melanomas by examining a multi-institutional international population. Methods Data were extracted on patients with T1 cutaneous melanoma who underwent SLNB between 2005 and 2018 at five tertiary centers in Europe and Canada. Univariable and multivariable logistic regression analyses were performed to identify predictors of SLNB positivity. Results Overall, 676 patients were analyzed. Most patients had one or more high-risk features: Breslow thickness 0.8–1 mm in 78.1% of patients, ulceration in 8.3%, mitotic rate > 1/mm 2 in 42.5%, Clark’s level ≥ 4 in 34.3%, lymphovascular invasion in 1.4%, nodular histology in 2.9%, and absence of tumor-infiltrating lymphocytes in 14.4%. Fifty-three patients (7.8%) had a positive SLNB. Breslow thickness and mitotic rate independently predicted SLNB positivity. The odds of positive SLNB increased by 50% for each 0.1 mm increase in thickness past 0.7 mm (95% confidence interval [CI] 1.05–2.13) and by 22% for each mitosis per mm 2 (95% CI 1.06–1.41). Patients who had one excised node (vs. two or more) were three times less likely to have a positive SLNB (3.6% vs. 9.6%; odds ratio 2.9 [1.3–7.7]). Conclusions Our international multi-institutional data confirm that Breslow thickness and mitotic rate independently predict SLNB positivity in patients with T1 melanoma. Even within this highly selected population, the number needed to diagnose is 13:1 (7.8%), indicating that more work is required to identify additional predictors of sentinel node positivity.