Details

Autor(en) / Beteiligte

• Hempe, James M.
• Hsia, Daniel S.

Titel

Variation in the hemoglobin glycation index

Ist Teil von

• Journal of diabetes and its complications, 2022-07, Vol.36 (7), p.108223-108223, Article 108223

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A high hemoglobin glycation index (HGI) has been repeatedly associated with greater risk for hypoglycemia in people with diabetes and greater risk for chronic vascular disease in people with or without diabetes. This review explores how different sources of analytical and biological variation in HbA1c and blood glucose individually and collectively affect the clinical information value of HGI. We conclude that HGI is a complex quantitative trait that is a clinically practical biomarker of risk for both hypoglycemia and chronic vascular disease. •The hemoglobin glycation index (HGI) quantifies variation in HbA1c due to factors other than blood glucose concentration.•High HGI is associated with greater risk for chronic vascular disease in people with or without diabetes•This review explores how analytical and biological sources of variation in HbA1c and blood glucose affect the clinical use of HGI.•HGI is a complex quantitative trait and a clinically practical biomarker of risk for chronic vascular disease.