Details

Autor(en) / Beteiligte

• Komarov, Igor V.
• Tolstanova, Ganna
• Kuznietsova, Halyna
• Dziubenko, Natalia
• Yanchuk, Petro I.
• Shtanova, Lydia Y.
• Veselsky, Stanislav P.
• Garmanchuk, Liudmyla V.
• Khranovska, Nataliia
• Gorbach, Oleksandr
• Dovbynchuk, Taisa
• Borysko, Petro
• Babii, Oleg
• Schober, Tim
• Ulrich, Anne S.
• Afonin, Sergii

Titel

Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data

Ist Teil von

• Journal of photochemistry and photobiology. B, Biology, 2022-08, Vol.233, p.112479-112479, Article 112479

Ort / Verlag

Switzerland: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the less toxic photoform (“ring-closed” dithienylethene) of the compound in tumors, plasma, and healthy liver. Accordingly, the peptide can reach a tumor concentration sufficiently high to exert a cytotoxic effect upon photoconversion into the more active (“ring-open”) photoform. Tissue morphology, histology, redox state of the liver, and hepatic biochemical parameters in blood serum were analysed upon treatment with (i) the less active photoform, (ii) the in vivo light-activated alternative photoform, and (iii) compared with a reference chemotherapeutic 5-fluorouracil. We found that application of the less toxic form followed by a delayed in vivo photoconversion into the more toxic ring-open form of LMB040 led to a higher overall survival of the animals, and signs of enhanced immune response were observed compared to the untreated animals. [Display omitted] •An in vivo application of a photoswitchable anticancer peptide.•Selection of a cancer model based on murine pharmacokinetic data.•A photopharmacology therapeutic experiment using chemically-induced HCC rat model.•Evidence for involvement of immune system upon photopharmacology therapy.