Details

Autor(en) / Beteiligte

• Sang, Zhipei
• Wang, Keren
• Dong, Jianghong
• Tang, Lei

Titel

Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

Ist Teil von

• European journal of medicinal chemistry, 2022-08, Vol.238, p.114464-114464, Article 114464

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting over 30 million people globally. Currently, no effective treatment is available due to multiple factors involved in the progression of AD. Given that the numerous AD-related targets in the disease network, the multi-target-directed ligands (MTDLs) strategy are considered as the promising strategy to treat AD. Herein, the multi-target compounds with/without ChEs are in clinical and in progress are reviewed. To further characterize the drug-likeness, and ADME properties are calculated using the Qikprop. This review will provide highlights for the treatment of AD. [Display omitted] •This work reviews multi-target strategies with ChEs inhibition.•This work reviews multi-target strategies without ChEs inhibition.•This work predicts ADME properties of the candidate compounds.