Details

Autor(en) / Beteiligte

• Church, Derek C
• Nourian, Saghar
• Lee, Chang-Uk
• Yakelis, Neal A
• Toscano, John P
• Boydston, Andrew J

Titel

Amphiphilic Copolymers Capable of Concomitant Release of HNO and Small Molecule Organics

Ist Teil von

• ACS macro letters, 2017-01, Vol.6 (1), p.46-49

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We demonstrate concomitant release of HNO and small molecule organics from amphiphilic poly­(norbornene)-based copolymers. This key function was achieved by incorporation of thermally labile oxazine units within random and block copolymer architectures. Upon thermolysis, we observed generation of HNO and release of a small molecule conjugate. Importantly, the release kinetics of HNO and a UV-active small molecule (4-nitroaniline) were found to be 1:1, signifying an ability to monitor HNO production indirectly, or to simultaneously release organic therapeutics (e.g., nonsteroidal anti-inflammatory drugs) along with HNO. To our knowledge, these are the first reported polymeric materials demonstrating HNO release from covalently attached HNO donors.