Details

Autor(en) / Beteiligte

• Tosun, M.N.
• Taylan, G.
• Demirel Zorba, N.N.

Titel

Antibacterial and antibiofilm activities of some plant essential oils and synergistic effects of cinnamon essential oil with vancomycin against Clostridioides difficile: in vitro study

Ist Teil von

• Letters in applied microbiology, 2022-09, Vol.75 (3), p.598-606

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The detection of resistant strains of Clostridioides difficile against existing antibiotics and the side effects led to the investigation of alternative agents. Inhibition zones of various essential oils to four strains of C.difficile and other Clostridium species ranged from 8·32 to 44·18 mm. The highest zone was observed in cinnamon and tea tree essential oils. and The MIC values varied between 0·39–25 (%, v/v). The main components were cinnamaldehyde (85·64%) in cinnamon essential oil, 4‐terpineol (83·6%) was determined in tea tree essential oil. Additive effects were found between cinnamon essential oil and vancomycin and between cinnamon and tea tree essential oils, and the FICI values were 0·512 and 0·517, respectively. Both cinnamon and tea tree essential oils showed antibiofilm activities against all tested C. difficile strains at all tested concentrations. Essential oils may be used as a supplement in addition to treatment in the control of C. difficile‐related diseases. Significance and Impact of the Study: Although standard antibiotic therapy is used to treat diseases associated with Clostridioides difficile, which is an important gastrointestinal pathogen, treatment failures and recurrence of infection create the need for alternative antimicrobial agents. The use of herbal natural products, especially cinnamon essential oil, as a food supplement in the treatment of C. difficile can be evaluated.