Details

Autor(en) / Beteiligte

• Zhu, Tianxing
• Jiang, Jiayi
• Xiao, Yitai
• Xu, Duo
• Liang, Zibin
• Bi, Lei
• Yang, Min
• Liang, Mingzhu
• Li, Dan
• Lin, Yong

Titel

Early Diagnosis of Murine Sepsis-Associated Encephalopathy Using Dynamic PET/CT Imaging and Multiparametric MRI

Ist Teil von

• Molecular imaging and biology, 2022-12, Vol.24 (6), p.928-939

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose Early diagnosis of sepsis-associated encephalopathy (SAE) is essential for the treatment and prognosis of septic patients. Static PET and MRI have shown promise for early diagnosis, while pharmacokinetic parameters from dynamic PET may provide better quantification for SAE. This study aims to compare the performance of dynamic 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]F-FDG) PET and multiparametric MRI in early imaging SAE with a view to providing guidance for the early diagnosis of SAE. Procedures Dynamic [ 18 F]F-FDG-PET/CT scans and multiparametric MRI were performed in SAE mice induced by LPS. Standardized uptake value (SUV) was measured in static scan images and [ 18 F]F-FDG pharmacokinetic parameters were analyzed with two-tissue compartment model and Patlak plot. MRI relative signal intensity (rT1) derived from T1-weighted images (pre and post contrast) and 4 parameters originating from diffusion-weighted data were measured. Results Both SUV and dephosphorylation rate constant ( k 4 ) increased in SAE model as early as 6 h post sepsis induction, while k 4 increased with the relative value (SAE/normal) significantly stronger than that of SUV. Moreover, the net influx constant ( K i ) showed significant decrease in SAE as early as 6 h compared with normal mice. Increased signal intensity was identified in T1-weighted contrast enhanced images and rT1 value increased at 12 h post induction. Diffusion tensor imaging (DTI) revealed fractional anisotropy (FA) decreased at 12 h and 24 h in external capsule (ec) and declined axial diffusivity (AD) was shown in white matter at 24 h. Conclusions The dynamic PET ( k 4 ) was more sensitive than static PET (SUV) for early diagnosis of SAE and declined K i was firstly found in murine SAE, which indicated the advantage of dynamic PET/CT in early detection and differential diagnosis of SAE. While MRI has a higher soft tissue resolution than PET/CT and can classify more subtle brain areas, the comprehensive utilization of the two modalities is helpful for managing SAE.