Details

Autor(en) / Beteiligte

• Wang, Lei
• Lu, Wenxin
• Zhang, Jiwu
• Chong, Qinglei
• Meng, Fanke

Titel

Cobalt‐Catalyzed Regio‐, Diastereo‐ and Enantioselective Intermolecular Hydrosilylation of 1,3‐Dienes with Prochiral Silanes

Ist Teil von

• Angewandte Chemie International Edition, 2022-07, Vol.61 (30), p.e202205624-n/a

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• One of the most straightforward approaches to access chiral silanes is catalytic enantioselective hydrosilylation. Although significant advances have been achieved in enantioselective construction of either a carbon‐stereogenic center or a silicon‐stereogenic center through enantioselective hydrosilylation, simultaneous establishment of a carbon‐ and a silicon‐stereogenic center in an acyclic molecule through a single intermolecular hydrosilylation remained undeveloped. Herein, an unprecedented cobalt‐catalyzed regio‐, diastereo‐ and enantioselective hydrosilylation of 1,3‐dienes is presented, enabling construction of a carbon‐ and a silicon‐stereogenic center in a single intermolecular transformation. A wide range of chiral silanes bearing a carbon‐ and a silicon‐stereogenic center were generated in high efficiency and stereoselectivity. Functionalization of the enantioenriched silanes delivered a variety of valuable chiral building blocks that are otherwise difficult to access. A new approach for highly regio‐, diastereo‐ and enantioselective intermolecular hydrosilylation of 1,3‐dienes promoted by an easily accessible Co complex to afford a wide range of enantioenriched acyclic silanes was developed. This protocol represents the first intermolecular example of simultaneous construction of a C‐ and a Si‐stereogenic center through metal‐catalyzed hydrosilylation.