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Diazaphospholene‐Catalyzed Radical Reactions from Aryl Halides
Ist Teil von
Angewandte Chemie International Edition, 2022-07, Vol.61 (30), p.e202204088-n/a
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2022
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Diazaphospholenes are widely used as hydride transfer catalysts, however their use in radical reactions is a recently emerging area. Here, we show prior stoichiometric radical cyclizations of aryl iodides mediated by diazaphospholene hydrides are made catalytic by the combination of phenylsilane and alkali metal salts to regenerate the diazaphospholene hydride. The scope was expanded to include aryl bromides, which benefit from visible light irradiation. Twenty one substrates underwent cyclization, including a dearomative cyclization. Extension to six intermolecular radical hydroarylations with arenes, thiophenes, and a pyridine was also accomplished.
Diazaphospholene radical chemistry has been made catalytic with a combination of carbonates and phenylsilane as a terminal reductant. The system is suitable for generation of aryl radicals and intermolecular and intramolecular addition of these radicals.