Details

Autor(en) / Beteiligte

• Pederiva, Cristina
• Capra, Maria Elena
• Biasucci, Giacomo
• Banderali, Giuseppe
• Fabrizi, Enrico
• Gazzotti, Marta
• Casula, Manuela
• Catapano, Alberico L.
• Arca, Marcello
• Averna, Maurizio
• Bertolini, Stefano
• Calandra, Sebastiano
• Catapano, Alberico Luigi
• Tarugi, Patrizia
• Pellegatta, Fabio
• Bartuli, Andrea
• Borghi, Claudio
• Calabrò, Paolo
• Carubbi, Francesca
• Cipollone, Francesco
• Citroni, Nadia
• Del Ben, Maria
• Fortunato, Giuliana
• Guardamagna, Ornella
• Iannuzzi, Arcangelo
• Iannuzzo, Gabriella
• Iughetti, Lorenzo
• Mandraffino, Giuseppe
• Maroni, Lorenzo
• Mombelli, Giuliana
• Muntoni, Sandro
• Parati, Gianfranco
• Passaro, Angelina
• Pisciotta, Livia
• Pujia, Arturo
• Purrello, Francesco
• Roscini, Anna Rita
• Sarzani, Riccardo
• Suppressa, Patrizia
• Werba, Josè Pablo
• Zambon, Sabina
• Zenti, Maria Grazia
• Allevi, Massimiliano
• Auricchio, Renata
• Baldera, Davide
• Bruzzi, Patrizia
• Bucci, Marco
• Buonuomo, Paola Sabrina
• Cefalù, Angelo Baldassarre
• Covetti, Giuseppe
• D'Addato, Sergio
• Di Taranto, Maria Donata
• Franceschi, Roberto
• Fimiani, Fabio
• Genovesi, Simonetta
• Grigore, Liliana
• Lupattelli, Graziana
• Madaghiele, Sara
• Massini, Giulia
• Minicocci, Ilenia
• Montalcini, Tiziana
• Nascimbeni, Fabio
• Pavanello, Chiara
• Perla, Francesco Massimo
• Peroni, Gaia
• Sani, Elena
• Scicali, Roberto
• Toscano, Arianna
• Vigna, Giovanni Battista
• Zambon, Alberto
• Galimberti, Federica
• Olmastroni, Elena
• Zampoleri, Veronica

Titel

Lipoprotein(a) and family history for cardiovascular disease in paediatric patients: A new frontier in cardiovascular risk stratification. Data from the LIPIGEN paediatric group

Ist Teil von

• Atherosclerosis, 2022-05, Vol.349, p.233-239

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Little is known about the role of Lp(a) in the assessment of cardiovascular risk in the paediatric population. Trying to clarify the clinical relevance of Lp(a) in risk stratification, the aim of the study is to evaluate the association between Lp(a) plasma levels in children with familial hypercholesterolaemia (FH) and positive family history for premature cardiovascular disease (pCVD) in first- and second-degree relatives. 653 Caucasian children and adolescents (334 females and 319 males), aged 2–17 years, with diagnosis of FH from a paediatric cohort included in the LIPIGEN Network, were selected. We compared family history of pCVD, lipid and genetic profile in two groups based on Lp(a) levels below or above 30 mg/dL. To determine the independent predictors of pCVD, a multivariate logistic regression was used, with all clinical characteristics and blood measurements as predictors. Subjects with Lp(a) > 30 mg/dl more frequently reported positive family history of pCVD compared to subjects with Lp(a)≤30 mg/dl (69.90% vs 36.66%, p < 0.0001), while did not show differences in terms of median [interquartile range] LDL-cholesterol level (153.00 [88.00 vs 164.50 [90.25] mg/dL, p = 0.3105). In the regression analysis, Lp(a) > 30 mg/dl was an independent predictor of family history of pCVD. Comparing subjects with or without family history of pCVD, we reported significant differences for Lp(a) > 30 mg/dl (46.25% vs 17.65%, p < 0.0001), FH genetic mutation (50.48% vs 40.75%, p = 0,0157), as well as for LDL-cholesterol (p = 0.0013) and total cholesterol (p = 0.0101). Children/adolescents with FH and Lp(a) > 30 mg/dl where more likely to have a positive family history of pCVD. Lp(a) screening in children and adolescents with FH may enhance risk assessment and help identify those subjects, children and relatives, at increased pCVD risk. [Display omitted] •Increased plasma Lp(a) concentration is an independent, causative genetic risk factor for cardiovascular disease.•Children with elevated Lp(a) levels have higher prevalence of family history of premature CVD (pCVD).•A family history of pCVD would appear to be predictive for elevated Lp(a) in children/adolescents.•Lp(a) testing in children may improve the identification of families at high cardiovascular risk.