Details

Autor(en) / Beteiligte

• Lonero, Antonella
• Giotta, Massimo
• Guerrini, Giulia
• Calcaterra, Valeria
• Galazzi, Elena
• Iughetti, Lorenzo
• Cassio, Alessandra
• Wasniewska, Gabriela Malgorzata
• Mameli, Chiara
• Tornese, Gianluca
• Salerno, Mariacarolina
• Cherubini, Valentino
• Caruso Nicoletti, Manuela
• Street, Maria Elisabeth
• Grandone, Anna
• Giacomozzi, Claudio
• Faienza, Maria Felicia
• Guzzetti, Chiara
• Bellone, Simonetta
• Parpagnoli, Maria
• Musolino, Gianluca
• Maggio, Maria Cristina
• Bozzola, Mauro
• Trerotoli, Paolo
• Delvecchio, Maurizio

Titel

Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model

Ist Teil von

• Journal of endocrinological investigation, 2022-09, Vol.45 (9), p.1709-1717

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose We aimed to evaluate the near-final height (nFHt) in a large cohort of pediatricpatients with growth hormone deficiency (GHD) and to elaborate a new predictive method of nFHt. Methods We recruited GHD patients diagnosed between 1987 and 2014 and followed-up until nFHt. To predict the values of nFHt, each predictor was run in a univariable spline. Results We enrolled 1051 patients. Pre-treatment height was −2.43 SDS, lower than parental height (THt) (−1.09 SDS, p < 0.001). The dose of recombinant human GH (rhGH) was 0.21mg/kg/week at start of treatment. nFHt was −1.08 SDS (height gain 1.27 SDS), higher than pre-treatment height ( p < 0.001) and comparable to THt. 1.6% of the patients were shorter than −2 SDS from THt. The rhGH dose at nFHt was 0.19 mg/kg/week, lower than at the start ( p < 0.001). The polynomial regression showed that nFHt was affected by gender, THt, age at puberty, height at puberty, age at the end of treatment ( F = 325.37, p < 0.0001, R 2 87.2%). Conclusion This large national study shows that GHD children can reach their THt. The rhGH/kg/day dose significantly decreased from the start to the end of the treatment. Our model suggests the importance of a timely diagnosis, possibly before puberty, the beneficial effect of long-term treatment with rhGH, and the key-role of THt. Our prediction model has a very acceptable error compared to the majority of other published studies.