Details

Autor(en) / Beteiligte

• Homma, Yuto
• Sugawara, Akihiro
• Morishita, Yohei
• Tsukada, Kento
• Ozaki, Taro
• Asai, Teigo

Titel

Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach

Ist Teil von

• Organic letters, 2022-05, Vol.24 (19), p.3504-3509

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new cyclic depsipeptide composed of l-leucine, l-tryptophan, and a polyketide moiety. Interestingly, the 10-membered macrocycle structure generated equilibrium to an unprecedented cyclol structure. This study demonstrates the advantage of a synthetic biology method in achieving rational access to new natural products.