Details

Autor(en) / Beteiligte

• Kolkhir, Pavel
• Kovalkova, Elena
• Chernov, Anton
• Danilycheva, Inna
• Krause, Karoline
• Sauer, Merle
• Shulzhenko, Andrey
• Fomina, Daria
• Maurer, Marcus

Titel

Reply to “Is anti-TPO IgG and total IgE clinically useful for the detection of autoimmune chronic spontaneous urticaria”?

Ist Teil von

• The journal of allergy and clinical immunology in practice (Cambridge, MA), 2022-05, Vol.10 (5), p.1393-1394

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• The diagnosis of aiCSU is based on 3 positive tests—the autologous serum skin test (autoreactivity), a basophil test (functionality), and immunoassays (quantitative identification of IgG autoantibodies against FcεRl and/or anti-IgE).3 Importantly, aiCSU comes with high disease activity, high rates of autoimmune comorbidities, poor quality of life, and poor response to treatment with antihistamines and omalizumab.3-5 It is, therefore, essential to bring biomarkers and predictors of aiCSU to routine clinical practice. [...]we measured IgE and aTPO levels only at 1 time point, although they can change over time, and this should also be taken into account in upcoming studies. Features/markers aiCSU References Angioedema Often 2,4 Nocturnal symptoms Often 4 Symptoms for > 5 d/wk Often 4 Disease activity (UAS7) High 2-4 Quality of life (DLQI) Low 4 Disease control (UCT) Low 4 Response to omalizumab Slow and/or poor 5 Total IgE Low 3,4,7 IgG-anti-TPO High 3,4 Total IgA Low 7 Blood basophil counts Low 3,6 Blood eosinophil counts Low 6 Table I Emerging features and markers of autoimmune chronic spontaneous urticaria diagnosed based on basophil testing (BAT and/or BHRA)∗