Details

Autor(en) / Beteiligte

• Galloo, Xavier
• Stassen, Jan
• Butcher, Steele C
• Meucci, Maria Chiara
• Dietz, Marlieke F
• Mertens, Bart J A
• Prihadi, Edgard A
• van der Bijl, Pieter
• Ajmone Marsan, Nina
• Braun, Jerry
• Bax, Jeroen J
• Delgado, Victoria

Titel

Staging right heart failure in patients with tricuspid regurgitation undergoing tricuspid surgery

Ist Teil von

• European journal of cardio-thoracic surgery, 2022-07, Vol.62 (2)

Ort / Verlag

Germany: Oxford University Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract OBJECTIVES This study evaluated the prognostic value of staging right heart failure in patients with significant tricuspid regurgitation (TR) undergoing tricuspid valve (TV) surgery. METHODS Patients with significant TR who underwent TV surgery were divided into 4 right heart failure stages according to the presence of right ventricular (RV) dysfunction and clinical signs of right heart failure: stage 1 was defined as no RV dysfunction and no signs of right heart failure; stage 2 indicated RV dysfunction without signs of right heart failure; stage 3 included RV dysfunction and signs of right heart failure; and stage 4 was defined as RV dysfunction and refractory signs of right heart failure at rest. RESULTS A total of 278 patients [mean age 64 (12), 49% males] were included, of whom 34 (12%) patients were classified as stages 1 and 2, 141 (51%) as stage 3 and 103 (37%) as stage 4 right heart failure. The majority of patients (91%) had TV surgery concomitant to left-sided valve surgery or coronary artery bypass grafting and 95% underwent TV annuloplasty. Cumulative survival rates were 89%, 78% and 61% at 1 month, 1 year and 5 years, respectively. Stages 1 and 2 and stage 3 were independently associated with better survival compared to stage 4 (hazard ratio: 0.391 [95% confidence interval: 0.186–0.823] and 0.548 [95% confidence interval: 0.369–0.813], respectively). CONCLUSIONS Patients with significant TR undergoing TV surgery and diagnosed without advanced right heart failure have better survival as compared to patients with right heart failure. The prognostic implications of severe tricuspid regurgitation (TR) have been reported in several patient cohorts and left untreated, severe TR is associated with poor survival [1, 2].