Details

Autor(en) / Beteiligte

• Griffin, Morag
• Langemeijer, Saskia
• Kulagin, Alexander
• Ogawa, Masayo
• Yu, Ji
• Peffault de Latour, Régis
• Latypova, Aigul
• Barcellini, Wilma
• Barraco, Fiorenza
• Beam, Donald
• Bettelheim, Peter
• Brodsky, Andres
• Carnley, Benedict
• Cermak, Jaroslav
• Chen, Tsai‐Yun
• Chew, Lee Ping
• Choi, Chul Won
• De Guibert, Sophie
• Devos, Timothy
• Dunaev, Yuri
• Dwilewicz‐Trojaczek, Jadwiga
• Edahiro, Yoko
• Elykomov, Iliya
• Engelberger, Maria Ines
• Pomponi, Fabrizio
• Fuereder, Wolfgang
• Fujii, Nobuharu
• Fujiwara, Shinichiro
• Girault, Stéphane
• Gomez Almaguer, David
• Gritsaev, Sergey
• Hantaweepant, Chattree
• Harada, Hiroshi
• Höglund, Martin
• Husin, Azlan
• Ikezoe, Takayuki
• Ishiyama, Ken
• Jang, Jun Ho
• Jo, Deog‐Yeon
• Kang, Ka‐Won
• Kennedy, James
• Kim, Hyo Jung
• Kim, Jeong‐A
• Kim, Jin Seok
• Kimura, Fumihiko
• Kosugi, Hiroshi
• Kulasekararaj, Austin
• Lai, Kuan‐Ming
• Lee, Gyeong‐Won
• Lee, Jae Hoon
• Lee, Je‐Hwan
• Lee, Jong Wook
• Lin, Chien‐Chin
• Martynova, Elena
• Matsumura, Itaru
• Meike, Galina
• Menosi Gualandro, Sandra Fátima
• Mori, Yasuo
• Morita, Kimio
• Morselli Ramalho, Fernanda Maria
• Muus, Petra
• Myasnikov, Alexander
• Naito, Kensuke
• Ninomiya, Haruhiko
• Notaro, Rosario
• Okada, Masaya
• Okamoto, Shinichiro
• Olkhovik, Tatiana
• Paquette, Ronald
• Park, Joon Seong
• Peffault de la Tour, Régis
• Piatek, Caroline
• Piekarska, Agnieszka
• Pospelova, Tatiana
• Rojnuckarin, Ponlapat
• Rosa Pessoa, Viviani de Lourdes
• Rossi, Blanca
• Salvino de Araujo, Marco Aurelio
• Samuel, Desmond
• Shatokhin, Yury
• Shelekhova, Tatiana
• Sohn, Sang Kyun
• Sunami, Kazutaka
• Syed Abdul Kadir, Sharifah Shahnaz
• Toh, See Guan
• Tomita, Akihiro
• Torregrosa Diaz, José Miguel
• Ueda, Yasutaka
• Usuki, Kensuke
• Viboonjuntra, Pongtep
• Viigimaa, Iige
• Volkova, Svetlana
• Won, Jong‐Ho
• Wong, Lily Lee Lee
• Wong, Voon Fei
• Yap, Eng Soo
• Yeh, Su‐Peng
• Yhim, Ho‐Young
• Zhuravkov, Andrey

Titel

Long‐term safety and efficacy of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria: 2‐year results from two pivotal phase 3 studies

Ist Teil von

• European journal of haematology, 2022-09, Vol.109 (3), p.205-214

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objectives The complement component 5 (C5) inhibitor ravulizumab demonstrated non‐inferiority to eculizumab following 26 weeks of treatment in complement inhibitor‐naïve and complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH; studies 301 and 302, respectively). This study aims to describe the results of both studies from 27 weeks to 2 years. Methods Patients (N = 441) continued to receive ravulizumab throughout the extension period. Efficacy endpoints included lactate dehydrogenase (LDH) normalization, transfusion avoidance and fatigue score (FACIT‐F). Safety analyses were also performed. Results From 27 weeks to 2 years, improvements in LDH levels were maintained in both study populations. Transfusion avoidance was maintained in 81.9% (study 301) and 85.6% (study 302) of patients, and FACIT‐F scores remained stable. Ravulizumab was well tolerated, and the incidence of adverse events (AEs) were similar between patients of both studies. Incidence of serious AEs deemed related to ravulizumab treatment was low (<3%). Conclusions This study reports, to date, the longest period of follow‐up in over 400 patients with PNH treated with ravulizumab (662 patient‐years). Long‐term, ravulizumab demonstrated durable efficacy and was well tolerated, highlighting the importance of C5 inhibitors as the mainstay of PNH treatment.