Details

Autor(en) / Beteiligte

• Serapio-Palacios, Antonio
• Woodward, Sarah E.
• Vogt, Stefanie L.
• Deng, Wanyin
• Creus-Cuadros, Anna
• Huus, Kelsey E.
• Cirstea, Mihai
• Gerrie, Madeleine
• Barcik, Weronika
• Yu, Hongbing
• Finlay, B. Brett

Titel

Type VI secretion systems of pathogenic and commensal bacteria mediate niche occupancy in the gut

Ist Teil von

• Cell reports (Cambridge), 2022-04, Vol.39 (4), p.110731-110731, Article 110731

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• The type VI secretion system (T6SS) is a contractile nanomachine widely distributed among pathogenic and commensal Gram-negative bacteria. The T6SS is used for inter-bacterial competition to directly kill competing species; however, its importance during bacterial infection in vivo remains poorly understood. We report that the murine pathogen Citrobacter rodentium, used as a model for human pathogenic Escherichia coli, harbors two functional T6SSs. C. rodentium employs its T6SS-1 to colonize the murine gastrointestinal tract by targeting commensal Enterobacteriaceae. We identify VgrG1 as a C. rodentium T6SS antibacterial effector, which exhibits toxicity in E. coli. Conversely, commensal prey species E. coli Mt1B1 employs two T6SSs of its own to counter C. rodentium colonization. Collectively, these data demonstrate that the T6SS is a potent weapon during bacterial competition and is used by both invading pathogens and resident microbiota to fight for a niche in the hostile gut environment. [Display omitted] •Enteric pathogen Citrobacter rodentium harbors two type VI secretion systems•C. rodentium T6SS-1 promotes colonization of the murine gastrointestinal tract•Murine commensal Escherichia coli Mt1B1 is a direct target of C. rodentium T6SS-1•E. coli also employs two T6SSs to directly compete with C. rodentium in the gut Serapio-Palacios et al. demonstrate that the enteric pathogen Citrobacter rodentium deploys a T6SS nanomachine to kill commensal Escherichia coli and promote colonization of the gastrointestinal tract. They also show that commensal prey E. coli employs a T6SS of its own to counteract the expansion of C. rodentium in the gut.