Details

Autor(en) / Beteiligte

• Minnen, Olivier
• Bergh, Walter M.
• Droogh, Joep M.
• Koehorst, Lisette
• Lagrand, Wim K.
• Raasveld, S. Jorinde
• Oude Lansink‐Hartgring, Annemieke
• Terpstra, Aart
• Smit, Jasper M.
• Tuinman, Pieter R.
• Vlaar, Alexander P. J.

Titel

Incidence and risk factors of deep vein thrombosis after extracorporeal life support

Ist Teil von

• Artificial organs, 2022-09, Vol.46 (9), p.1893-1900

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Wiley Online Library Journals【Remote access available】

Beschreibungen/Notizen

• Background Deep vein thrombosis (DVT) after decannulation of extracorporeal life support (ECLS) is not uncommon. Moreover, the impact of anticoagulation and potential risk factors is unclear. Furthermore, it is unclear if cannula‐associated DVT is more common in ECLS patients compared to critically ill patients without ECLS. Methods All adult patients who were successfully weaned from ECLS and were screened for DVT following decannulation were included in this observational cohort study. The incidence of post‐ECLS‐DVT was assessed and the cannula‐associated DVT rate was compared with that of patients without ECLS after central venous catheter (CVC) removal. The correlation between the level of anticoagulation, risk factors, and post‐ECLS‐DVT was determined. Results We included 30 ECLS patients and 53 non‐ECLS patients. DVT was found in 15 patients (50%) of which 10 patients had a DVT in a cannulated vein. No correlation between the level of anticoagulation and DVT was found. V‐V ECLS mode was the only independent risk factor for post‐ECLS‐DVT (OR 5.5; 95%CI 1.16–26.41). We found no difference between the ECLS and non‐ECLS cohorts regarding cannula‐associated DVT rate (33% vs. 32%). Conclusion Post‐ECLS‐DVT is a common finding that occurs in half of all patients supported with ECLS. The incidence of cannula‐associated DVT was equal to CVC‐associated DVT in critically ill patients without ECLS. V‐V ECLS was an independent risk factor for post‐ECLS‐DVT. DVT following ECLS is frequent with half the patients showing DVT after decannulation. However, similar cannula‐associated DVT rates in ECLS patients compared to CVC‐associated DVT rates in a non‐ECLS cohort of critically ill patients were found. We identified V‐V ECLS as an independent risk factor for post‐ECLS‐DVT. The level of anticoagulation based on aPTT values was not associated with the occurrence of post‐ECLS‐DVT. Further research is needed to reveal the clinical relevance of post‐ECLS‐DVT and factors associated with cannula‐associated DVT.