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Details

Autor(en) / Beteiligte
Titel
Avoiding N-nitrosodimethylamine formation in metformin pharmaceuticals by limiting dimethylamine and nitrite
Ist Teil von
  • International journal of pharmaceutics, 2022-05, Vol.620, p.121740-121740, Article 121740
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
  • [Display omitted] Since late 2019, concerns regarding trace levels of the probable human carcinogen N-dimethylnitrosamine (NDMA) in Metformin-containing pharmaceuticals have been an issue if they exceeded the maximum allowable intake of 96 ng/day for a medicine with long-term intake. Here, we report results from an extensive analysis of NDMA content along the active pharmaceutical ingredient (API) manufacturing process as well as two different drug product manufacturing processes. Our findings confirm that Metformin API is not a significant source of NDMA found in Metformin pharmaceuticals and that NDMA is created at those steps of the drug product manufacturing that introduce heat and nitrite. We demonstrate that reduction of nitrite from excipients is an effective means to reduce NDMA in the drug product. Limiting residual dimethylamine in the API has proven to be another important factor for NDMA control as dimethylamine leads to formation of NDMA in the drug products. Furthermore, analysis of historical batches of drug products has shown that NDMA may increase during storage, but the levels reached were not shelf-life limiting for the products under study.
Sprache
Englisch
Identifikatoren
ISSN: 0378-5173, 1873-3476
eISSN: 1873-3476
DOI: 10.1016/j.ijpharm.2022.121740
Titel-ID: cdi_proquest_miscellaneous_2651692566

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